| PIEZO1 | |||||||||
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| Identifiers | |||||||||
| Aliases | PIEZO1, DHS, FAM38A, Mib, LMPH3, piezo type mechanosensitive ion channel component 1, LMPHM6 | ||||||||
| External IDs | OMIM: 611184MGI: 3603204HomoloGene: 124356GeneCards: PIEZO1 | ||||||||
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| Species | Human | Mouse | |||||||
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| Location (UCSC) | Chr 16: 88.72 – 88.79 Mb | Chr 8: 122.48 – 122.55 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| Wikidata | |||||||||
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SeekEC 12.8.6.5mm pin piezoelectric high frequency 4K 5V micro buzzer. US $0.13-$0.24 / Piece. Order) CN Shenzhen Maoxing Weiye Technology Co., Ltd. PIEZO2 (Piezo Type Mechanosensitive Ion Channel Component 2) is a Protein Coding gene. Diseases associated with PIEZO2 include Marden-Walker Syndrome and Arthrogryposis, Distal, Type 5.Gene Ontology (GO) annotations related to this gene include cation channel activity and mechanosensitive ion channel activity. APC International, Ltd. Is a leading global supplier of piezoelectric ceramic shapes, piezoelectric transducers, piezo devices, and piezo application support services. Since 1986, APC has been recognized for providing value to its customers by manufacturing high-quality custom piezo products and delivering a superior level of customer ser.
Piezo1 is a mechanosensitive ion channel protein that in humans is encoded by the gene PIEZO1. Piezo1 and its close homolog Piezo2 were cloned in 2010, using an siRNA-based screen for mechanosensitive ion channels.[5] Alien skin exposure x3 bundle 3 5 4 114.
Structure and function[edit]
PIEZO1 (this gene) and PIEZO2 share 47% identity with each other and they have no similarity to any other protein and contain no known protein domains. They are predicted to have 24-36 transmembrane domains, depending on the prediction algorithm used. In the original publication the authors were careful not to call the piezo proteins ion channels, but a more recent study by the same lab convincingly demonstrated that indeed piezo1 is the pore forming subunit of a mechanosensitive channel.[6]
It is assumed that Piezo1 channel is a three-bladed propeller-like structure and a lever-like mechanogating mechanism.[7][8]
Tissue distribution[edit]
Piezo1 is expressed in the lungs, bladder and skin, where mechanosensation has important biological roles. Unlike Piezo2 which is highly expressed in sensory dorsal root ganglia, piezo1 is not expressed in sensory neurons.[5]
Clinical significance[edit]
Piezo 1 6 4k Hdr
Piezo1 is also found in red blood cells, and gain of function mutations in the channels are associated with hereditary xerocytosis or stomatocytosis.[9][10][11] Piezo1 channels are pivotal integrators in vascular biology.[12]
Piezo 1 6 4k Led
An allele of Piezo1, E756del, results in a gain-of-function mutation, resulting in dehydrated RBCs and conveying resistance to Plasmodium. This allele has been demonstrated in vitro to prevent cerebral malaria infection.[13]
Piezo1 has been implicated in extrusion of epidermal cells when a layer becomes too confluent to preserve normal skin homeostasis. This acts to prevent excess proliferation of skin tissue, and has been implicated in cancer biology as a contributing factor to metastases by assisting living cells in escaping from a monolayer.[14]
Expression of murine PIEZO1 in mouse innate immune cells is essential for their function, a role mediated by sensing mechanical cues. Deficiency in PIEZO1 in mice lead to increased susceptibility of myeloid cells to infection by Pseudomonas aeruginosa.[15]
Ligands[edit]
- Agonists
- Yoda1 (small molecule agonist)[16]
References[edit]
Piezo 1 6 4k Uhd
- ^ abcGRCh38: Ensembl release 89: ENSG00000103335 - Ensembl, May 2017
- ^ abcGRCm38: Ensembl release 89: ENSMUSG00000014444 - Ensembl, May 2017
- ^'Human PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^'Mouse PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ abCoste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, et al. (October 2010). 'Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels'. Science. 330 (6000): 55–60. Bibcode:2010Sci..330..55C. doi:10.1126/science.1193270. PMC3062430. PMID20813920.
- ^Coste B, Xiao B, Santos JS, Syeda R, Grandl J, Spencer KS, et al. (February 2012). 'Piezo proteins are pore-forming subunits of mechanically activated channels'. Nature. 483 (7388): 176–81. Bibcode:2012Natur.483.176C. doi:10.1038/nature10812. PMC3297710. PMID22343900.
- ^Zhao Q, Zhou H, Li X, Xiao B (July 2019). 'The mechanosensitive Piezo1 channel: a three-bladed propeller-like structure and a lever-like mechanogating mechanism'. The FEBS Journal. 286 (13): 2461–2470. doi:10.1111/febs.14711. PMID30500111.
- ^Wang Y, Chi S, Guo H, Li G, Wang L, Zhao Q, et al. (April 2018). 'A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel'. Nature Communications. 9 (1): 1300. Bibcode:2018NatCo..9.1300W. doi:10.1038/s41467-018-03570-9. PMC5880808. PMID29610524.
- ^Zarychanski R, Schulz VP, Houston BL, Maksimova Y, Houston DS, Smith B, et al. (August 2012). 'Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis'. Blood. 120 (9): 1908–15. doi:10.1182/blood-2012-04-422253. PMC3448561. PMID22529292.
- ^Bae C, Gnanasambandam R, Nicolai C, Sachs F, Gottlieb PA (March 2013). 'Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1'. Proceedings of the National Academy of Sciences of the United States of America. 110 (12): E1162-8. Bibcode:2013PNAS.110E1162B. doi:10.1073/pnas.1219777110. PMC3606986. PMID23487776.
- ^Albuisson J, Murthy SE, Bandell M, Coste B, Louis-Dit-Picard H, Mathur J, et al. (2013). 'Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels'. Nature Communications. 4: 1884. Bibcode:2013NatCo..4.1884A. doi:10.1038/ncomms2899. PMC3674779. PMID23695678.
- ^Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, et al. (November 2014). 'Piezo1 integration of vascular architecture with physiological force'. Nature. 515 (7526): 279–282. Bibcode:2014Natur.515.279L. doi:10.1038/nature13701. PMC4230887. PMID25119035.
- ^Ma S, Cahalan S, LaMonte G, Grubaugh ND, Zeng W, Murthy SE, et al. (April 2018). 'Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection'. Cell. 173 (2): 443–455.e12. doi:10.1016/j.cell.2018.02.047. PMC5889333. PMID29576450.
- ^Eisenhoffer GT, Loftus PD, Yoshigi M, Otsuna H, Chien CB, Morcos PA, Rosenblatt J (April 2012). 'Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia'. Nature. 484 (7395): 546–9. Bibcode:2012Natur.484.546E. doi:10.1038/nature10999. PMC4593481. PMID22504183.
- ^Solis AG, Bielecki P, Steach HR, Sharma L, Harman CC, Yun S, et al. (September 2019). 'Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity'. Nature. 573 (7772): 69–74. Bibcode:2019Natur.573..69S. doi:10.1038/s41586-019-1485-8. PMC6939392. PMID31435009.
- ^Syeda R, Xu J, Dubin AE, Coste B, Mathur J, Huynh T, et al. (May 2015). 'Chemical activation of the mechanotransduction channel Piezo1'. eLife. 4. doi:10.7554/eLife.07369. PMC4456433. PMID26001275.
